Epigenetics, 1-Carbon Metabolism, and Homocysteine During Dysbiosis
نویسندگان
چکیده
منابع مشابه
Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies.
Folate-mediated 1-carbon metabolism is a network of interconnected metabolic pathways necessary for the synthesis of purine nucleotides, thymidylate and the remethylation of homocysteine to methionine. Disruptions in this pathway influence both DNA synthesis and stability and chromatin methylation, and result from nutritional deficiencies and common gene variants. The mechanisms underlying fola...
متن کاملOne-Carbon Metabolism and Alzheimer’s Disease: Focus on Epigenetics
Alzheimer's disease (AD) represents the most common form of dementia in the elderly, characterized by progressive loss of memory and cognitive capacity severe enough to interfere with daily functioning and the quality of life. Rare, fully penetrant mutations in three genes (APP, PSEN1 and PSEN2) are responsible for familial forms of the disease. However, more than 90% of AD is sporadic, likely ...
متن کاملMetabolism & epigenetics
Epigenetic regulation of gene activity is of immense importance in maintaining normal and dynamic transcription profiles of practically all cells in our body. In the meantime, cells metabolize nutrients to sustain through different tasks and challenges of life. Both metabolism and gene activity respond to changes in environment. By assessing the relative abundance of certain key compounds centr...
متن کاملBridging epigenetics and metabolism
Recent research suggests that chromatin-modifying enzymes are metabolic sensors regulating gene expression. Epigenetics is linked to metabolomics in response to the cellular microenvironment. Specific metabolites involved in this sensing mechanism include S-adenosylmethionine, acetyl-CoA, alphaketoglutarate and NAD (+) . Although the core metabolic pathways involving glucose have been emphasize...
متن کاملEpigenetics and Cellular Metabolism
Living eukaryotic systems evolve delicate cellular mechanisms for responding to various environmental signals. Among them, epigenetic machinery (DNA methylation, histone modifications, microRNAs, etc.) is the hub in transducing external stimuli into transcriptional response. Emerging evidence reveals the concept that epigenetic signatures are essential for the proper maintenance of cellular met...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Physiology
سال: 2021
ISSN: 1664-042X
DOI: 10.3389/fphys.2020.617953